How does this medicine work?
Topotecan (toh-poh-tee-kan) is a chemotherapy medicine that destroys cancer cells by interfering with a specific phase of cell life.
How is it given?
It is given into the vein (IV) in the hospital or clinic. Sometimes it is given intrathecally (into the spinal fluid).
What are the side effects?
For patients receiving IV topotecan:
Common
- low blood counts
- fatigue
- mild nausea, vomiting, and diarrhea
- hair loss
Occasional
- mouth sores
- rash
- fever and flu-like symptoms
- headaches
- low blood pressure
- shortness of breath
Rare
- abdominal (belly) pain
- kidney or liver problems
- signs of allergic reaction:
- fever or chills
- rash or hives
- wheezing
- trouble breathing
For patients receiving intrathecal topotecan:
Occasional
- nausea and vomiting
- fever
- headaches
Rare
- seizures
- paralysis
- changes in the brain tissue seen on MRIs, which may indicate learning disabilities