How does this medicine work?
Thiotepa (thi-oh-tep-ah) is used to treat certain types of cancer. It destroys cancer cells’ ability to divide.
How is it given?
Thiotepa is given into a vein (IV) during a hospital stay.
Are there any precautions about food or other medicines?
Thiotepa cannot be given when the patient is receiving total parenteral nutrition (TPN).Protein in the TPN may interfere with how the body breaks down the thiotepa. On the days thiotepa is given, and for 24 hours afterward, regular IV fluids are given.
What are the side effects?
Common
- low blood cell counts
- loss of appetite
- nausea, vomiting
- mouth and throat sores
- hair loss
- rash, itching
- darkened, peeling skin
- increased sun sensitivity
- infertility
Occasional
- stomach ulcers
- headache
- dizziness
- sleepiness
- severe skin breakdown
- blurred vision
Rare
- hives
- bleeding in the bladder
- if child has had previous radiation to the head: behavior changes, forgetfulness, confusion
- liver injury
- kidney injury
When should I call the clinic?
Call hematology helpline 982403210 if:
- fever or chills
- rash
- redness or breakdown of skin
- mouth sores
- abdominal (belly) pain
- rash or hives
- wheezing
- trouble breathing – call 112