How does this medicine work?

Temozolomide (te-moh-zol-oh-mide) destroys cancer cells in all phases of cell life.

How is it given?

Temozolomide is given by mouth. It comes in capsule form and should be swallowed whole. It should be given at regular times to keep a steady level in the bloodstream.

For children who cannot swallow capsules:

  • Put on gloves.
  • Open capsule inside a clear plastic bag.
  • Mix the powder with a very small amount (1 teaspoon) of soft food, such as applesauce or applejuice. Make sure your child takes all of the mixture.
  • Wash spoons and container right after use. Discard the plastic bag and gloves.

Are there any precautions about food or other medications?

Temozolomide should be taken on an empty stomach with water only, to reduce nausea and to help the body to absorb and use the medicine. It needs to be taken at a consistent time each day with regard to meals.

Check with the doctor, nurse practitioner, or pharmacist before giving any other prescription or non-prescription medicines, herbs, or vitamins.

What should I do if a dose is missed?

If a dose is missed, give it as soon as you remember that day. Never give a double dose.
If your child vomits within 30 minutes after receiving a dose, give it again. If your child vomits after 30 minutes, do not repeat the dose.

Call the oncology clinic if more than one dose is missed or vomited.

What are the side effects?


  • low blood counts
  • nausea
  • vomiting
  • constipation
  • headaches


  • hair loss
  • mouth sores
  • fatigue
  • liver problems
  • skin rash
  • coordination problems

When should I call the clinic?

Call hematology helpline 982403210 if:

  • fever or chills
  • mouth sores
  • continued vomiting or diarrhea
  • bleeding or unusual bruising
  • skin rash
  • change in coordination
  • increasing headache
  • no bowel movement for 2 days or longer
  • signs of an allergic reaction
    • rash or hives
    • wheezing

What else do I need to know?

All caregivers should wear gloves when handling urine, stool, and vomit while your child is receiving the chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.

Before starting temozolomide, a pregnancy test will be done on any girl who has begun menstruating.

A high-fiber diet or stool softener may be given to prevent or treat constipation.

You and your child should know the names of all the medicines he or she is taking. It is important to share this information with anyone involved in your child’s care.


This sheet is not specific to your child but provides general information. If you have any questions, please call:

Hematology Clinic
3rd floor, Kedar
Opp.Krupa Petrol Pump,
Parimal Garden, Ambawadi
Clinic: 07926463219
Whattsapp: 8238065890