How does this medicine work?

Leucovorin (loo-ko-vor-in) is a vitamin that stops the chemotherapy medicine methotrexate from harming normal cells. It is usually given after a high dose of methotrexate.

How should I give it?

Leucovorin is given by mouth as a pill or liquid, or as an injection into a vein, as directed by the doctor.

This medicine must be given on time. If not taken on time, more healthy cell damage occurs from increased side effects of methotrexate. Your child should be awake and alert when taking any medicine.

For children who cannot swallow pills

  • Crush the tablet in a tablet crusher or between 2 spoons inside a clear plastic bag.
  • Mix the powder with a very small amount of soft food, such as applesauce, jelly, or chocolate syrup.
  • Make sure your child takes all of the mixture.

Are there any precautions about food or other medicines?

Leucovorin may be taken with or without food.

Check with the doctor, nurse practitioner, or pharmacist before giving any other prescription or non-prescription medicines, herbs, or vitamins.

What should I do if a dose is missed?

If one dose is missed, call your provider to determine how the dose should be made up.

If your child throws up within 30 minutes after receiving a dose, give it again. If your child vomits after 30 minutes, call the oncology clinic or your doctor for further instructions.

What are the side effects?

  • mild nausea
  • vomiting
  • allergic reaction:
    • rash, itching
    • redness of the skin

When should I call the clinic?

Call the helpline: 982403210 if:
Any side effects occur. If signs of allergic reaction occur, call right away!

What else do I need to know?

You and your child should know the names of all the medicines he or she is taking. It is important to share this information with anyone involved in your child’s care.

Always make sure you have enough medicine on hand as the pharmacy may need 2 or 3 days to refill the prescription. Check the label for the expiration date.
Flush outdated medicines down the toilet instead of putting them in the garbage.

If too much or the wrong kind of medicine is taken, call the oncology clinic right away.


This sheet is not specific to your child but provides general information. If you have any questions, please call:

Hematology Clinic
3rd floor, Kedar
Opp.Krupa Petrol Pump,
Parimal Garden, Ambawadi
Clinic: 07926463219