How does this medicine work?
Bortezomib (bor tez’ o mib) is a biological cancer medicine from a new group of drugs called proteasome inhibitors. It works to destroy cancer cells by blocking the breakdown of proteins within the cell.
How is the medicine given?
Bortezomib is given into a vein (IV) in the hospital or clinic.
Are there any precautions about food or other medicines?
There are some foods, drinks, and dietary supplements that can interfere with the action of Bortezomib. You should stop taking them at least one day before starting Bortezomib and not start them until at least 72 hours after the last dose. These include:
- Vitamin products containing vitamin C and antioxidants
- Foods with high vitamin C content, such as fruits and juices (citrus fruits and juices)
- Green tea and any herbal products and any products containing flavanoids or other antioxidant compounds
Some medications can interfere with bortezomib. Let your provider know all the medications you are taking including over the counter medications and herbal products.
Lightheadedness may occur when getting up quickly from a lying position. To avoid this,get out of bed slowly and rest your feet on the floor for a few minutes before standing.
What are the side effects?
Common
- Nausea/ Vomiting
- Fatigue
- Hair loss
- Decreased appetite
- Constipation or diarrhea
- Low platelet count
- Swelling of the arms and legs
Occasional
- Pain, burning, numbness, or tingling of the hands or feet (peripheral neuropathy)
- Fever
- Headache
- Muscle weakness
- Fainting
- Insomnia
- Cough
- Rash
- Increased risk of infection
- Pain (abdomen, back, bone, limb, head, hands, or feet)
- Low hemoglobin
- Low potassium, calcium or phosphorus levels
Rare
- Congestive heart failure
- Acute liver dysfunction
- Acute respiratory distress syndrome
- Low blood pressure